Tylosin For Dogs

Tylan Powder
Tylosin for Dogs


Tylosin is a naturally-produced macrolide substance that has been used in veterinary medicine for many decades. While originally used to treat diseases that were not responsive to other drugs in poultry and farm animals, it is now commonly administered to cats and dogs as an antibiotic for treatment of colitis, intestinal bacteria, and soft tissue infections. It is also very used as an effective Tear Stain remover in dogs and other animals. If you would like to buy Tylosin Powder, click here.


The fact that it is a macrolide means that it works by having a bacteriostatic effect on susceptible organisms. It stalls an infection, rather than stopping it, giving the immune system time to catch up. It does this by inhibiting the synthesis of RNA dependent protein and works very well against what is termed as gram positive bacteria. Many are of the view that is necessary to try using other treatments before resorting to Tylosin, however depending on its intended use this may not be the case. One such case where it’s advisable to use Tylosin from the onset is when treating Tear Stains. We will get to the benefits of this later on in the article.

Bacterial Infections and Tylosin

Because of Tylosin’s strong anti-bacterial properties, it is primarily used to fight against bacterial infection in farm and poultry animals. Produced from an actinomycetes Streptomyces fradiae, as a macrolide antibiotic it is often used to treat diseases that are unresponsive to other treatment.

It is important to mention that Tylosin is not approved for use in domestic animals by the Food and Drug Administration (FDA) for the treatment of bacterial infections in domestic animals, but it is a prescription extra-label drug that can be legally obtained from veterinarians and is best administered by professionals. Tylosin however does not require a prescription for the treatment of Tear Stains in dogs and Tylosin Responsive Diarrhea. Over the decades, Tylosin has also been used on farm animals such as pigs and cows to boost their physical growth and prevent the spread of infectious diseases. Lets delve a little into the ingredients that make up Tylosin.


Ingredients Found in Tylosin

Ingredients in Tylosin

Tylosin is commonly available in three forms; Injectable liquid, soluble granules and soluble powder. It possesses a broad spectrum of activity against gram-positive organisms and a limited range of gram-negative organisms. They are composed of four major components, Tylosin A, B, C, and D. Tylosin A are the major component; however, B, C, D contribute to the overall potency of the substance.


Dosages for Tylosin powder will vary depending on the condition it is intended to treat and the weight of your dog. Tylosin comes in different formats, either powder or liquid and they are administered orally or by injection. In 1976, Van Kruingen was the first person to raise awareness on the use of Tylosin of in treating colitis on dogs. He performed a study about the clinical efficacy of Tylosin in canine inflammatory bowel diseases.

The study which was performed on 27 dogs, who were receiving an oral dosage of Tylosin between 11 – 200 mg/kg. Their dosing interval was twice daily and the duration of their treatment varied from one week to five years. A few decades later, a study was performed on seven dogs suffering from secondary chronic diarrhea due to naturally occurring exocrine pancreatic insufficiency.

These dogs received Tylosin for 5-6 days at a dose of 15mg/kg twice daily as an adjunctive medication to the pancreatic enzyme. And in 2005, Westermarck et al. introduced the term Tylosin responsive diarrhea. In a case series involving nine clients owned dogs suffering from recurrent diarrhea and responding to Tylosin at a dose of 6 – 16 mg/kg once daily for two weeks.

Here is a very helpful chart with the recommended dosages for Tear Stain removal:

Tylosin powder dosage
Dosage for Tylosin powder for Tear Stain in dogs


What is Tylosin Used For?

Tylosin for dogs
Uses of Tylosin

Tylosin is most commonly used in dogs for two reasons: Relief from digestive issues and cosmetic benefits. In small mammals it is more commonly used for its ant-inflammatory properties rather than its antibiotic properties, primarily in the treatment of Colitis.

Relief from a variety of digestive disorders

Tylosin can be used to treat many different disorders of the digestive tract, such as chronic diarrhea, colitis, inflammatory bowel disease and exocrine pancreatic insufficiency, particularly when other drugs have been found ineffective. It is often given to dogs with diarrhea associated with above-mentioned disorders. Tylosin works quickly and its anti-inflammatory properties can offer a dog significant relief from symptoms of an overworked and painful intestine.

Treating Infections and Tear Stain Removal

Tylosin is prescribed to resolve excessive tear stain production in dogs and cats in an effort to prevent staining or discoloration of their coats. It has become increasingly popular with small breeds of dogs such as Shit-Tzu and Maltese, which are very prone to the development of tear stains.

Over the decades, Tylosin has been served as a means of treating chronic diseases such as diarrhea and aiding the treatment of repository and digestive infection in animals. In poultry, chicken and turkeys are administered Tylosin to treat an unresponsive respiratory infection. It is also known to allow the treatment of infectious diseases that are less susceptible to drugs (other antibiotic substance) such as chronic diarrhea, colitis, exocrine pancreatic etc. 

Tylosin can be used to treat a broad spectrum of diseases across the world because it differs in formulations, administration, medication and approval for treatment in many countries. For instance, small animals are given Tylosin as a form of treating colitis, while animals such as white coated dogs that suffer from epiphora, tear staining are administered Tylosin to improve the appearance of their fur.

Other infections that can be treated with Tylosin are respiratory infections, Metritis and Acute Mastitis in cattle; Mastitis in sheep and goats; Enteritis, Pneumonia, Erysipelas and infectious arthritis in swine, and soft tissue infections in small animals.

Finally, Tylosin can be used on a long term basis. It is safe for long term use and it provides a good alternative to metronidazole, another bowel anti-inflammatory antibiotic that is not as amenable to long term use.


Seek Advice from Your Vet before Use

Consult Vet before use

But before applying Tylosin to treat these diseases or infections, it is advisable to make use of other antibiotics first or seek the advice of a veterinary professional as that is more preferable. Still, Tylosin can be used on ferrets, rabbits, birds, reptiles, and pockets pets etc.

This macrolide substance can also be used to treat other infections of the organ system, notable the respiratory tract and the skin. Despite the numerous usage of Tylosin, it can’t be given to horses as it increases their blood levels and disrupts their immune substance.

Side Effects of Tylosin on Dogs

Side Effects of Tylosin

Since Tylosin is yet to be approved by the FDA (Food and Drug Administration) for the treatment of dogs and cats, it means that only veterinary professionals should administer the substance to prevent the animals from suffering from its side effect. These side effects can cause serious potential damage to the health of the patient. It is important to know the side effect to avoid damages. 

Long Term Use

Firstly, the long term use of Tylosin can put a dog at risk, their immune system may develop resistance to other antibiotics medications that may be necessary to treat other diseases or infections in the future. This negative mutation causes their immune system to develop antibiotic resistance to other treatment when fighting new diseases or infections.

Possibility of Relapse and Tylosin Responsive Diarrhea

There is also a high tendency of relapse of the infection or disease.  Scientist are yet to understand the substance properly, they report that the application of Tylosin may worsen the problems it intends to solve. This may occur in the treatment of chronic diarrhea and it is referred to as Tylosin Responsive Diarrhea (TRD).

Tylosin Responsive Diarrhea means that the medication could offer a quick solution to the dog’s digestive upset or infection, but there is a possibility that it may return within a few weeks of coming off the medications.

Animals with Hypersensitivity

Another side effect is that Tylosin cannot be administered to animals with known hyper-sensitivity or allergy to the drug or other macrolide antibiotics. The administration of the substance may worsen the problem it intends to solve.  It is also reported that Tylosin does not react well with other antibiotic dosages.

Weakened Immune System of Some Dogs

The substance does not react well with secondary substances and it can weaken the immune system of the dog and leave it susceptible to other mild diseases in the future. This is one of the reason it is important to seek the assistance of a veterinary professional before the administration or the medication of Tylosin.

Increase in Blood Pressure

Tylosin, when administered to dogs, can increase their blood pressure. When it comes into contact with other substance in the body, the reaction can increase the level of toxicity in the body which may have a negative effect on the animal.

Tylosin also has a foul taste, which is often hard to disguise or take into the body.  This is a minor effect that results from the oral administration of the substance. The foul taste often causes the patient to shy away from oral administration of the substance of the substance itself. 

In conclusion, some of the minor side effects that may result from the use of Tylosin include pain and local irritations at the injection site, diarrhea, anorexia, and an increase in blood levels.

While not necessarily side effects, there are quite a few issues associated with the use of Tylosin that should be seriously considered.


As with any other medicine, Tylosin should not be given to dogs with known hypersensitivity or allergy to the drug or other macrolide antibiotics

Bad Taste

Tylosin has a particularly strong and unpleasant taste that is hard to disguise, making oral administration to dogs quite difficult. Gastrointestinal disturbance, resulting in diarrhea, may occur right after oral administration

Skin Itching

When administering via injection, skin itching may occur around the spot of injection.


Tylosin is an antibiotic, which means it carries the risk of a dog developing resistance to it, making it increasingly difficult for its body to fight off future infections.

Log Term Use

Long-term effects of use of Tylosin have not been researched enough: Because of this, it is important to consider alternatives before resorting to Tylosin. For example, billberry extract is a great natural alternative to Tylosin which can help with tear staining. Studies state that Tylosin’s mechanisms of action are not fully understood yet and that its successes are anecdotal rather than scientific. This is why long-term use is not advocated


Use with other antibiotics: It is reported that Tylosin does not react well with other antibiotics. When it comes into contact with other substances in the body, the reactions can dangerously increase levels of toxicity

Increase in Blood Pressure

It has been reported that Tylosin can increase dogs’ blood pressure


  • As a substance that works by helping the immune system rather than fighting a disease, there is also a high tendency of relapse of the infection: For this reason, it is suggested that Tylosin is better used as a last resort option when other drugs have failed to resolve the underlying health issue.

When Tylosin is given to a dog for the first time, owners should monitor it closely to make sure there are no serious side effects. If there is any change in the behavior of the dog, it is important to discontinue use.

Correct Dosage of Tylosin

There is no definite recommendation of the administration of Tylosin on dogs or cats due to certain factors ranging from the nature of the illness, the weight and age of the animal. For this reason, veterinary professional advice or recommendation must be considered before the treatment of an infection with Tylosin.

Tylosin varies widely so as the prescription and administration vary too.  Tylosin comes in different dosages and format and administered differently (either orally or through injection). They can be in form of powder, injectable oral liquid and capsule formulations.

The duration of administration depends on the condition being treated, the response to the substance and subsequent development. In dogs, the usual dose is 5 to 10 mg or 10 to 20 mg/kg every 2 hours for up to six weeks.  A recent random study showed the effect of Tylosin on fecal consistency in dogs with recurrent diarrhea. At a dose of 25mg/kg once daily for seventy days, Tylosin proved more effective than placebo.

it is important to mention that there is no standard recommendation of the administration of Tylosin on dogs due to factors ranging from the nature of the illness, the weight and age of the animal. For this reason, veterinary professional advice or recommendation must be considered before the treatment of an infection with Tylosin. Doses can vary widely depending on the reason for prescribing.

The duration of administration depends on the condition being treated, the response to the substance and subsequent development. A study on the effect of Tylosin on fecal consistency in dogs with recurrent diarrhea proved to be very successful at a dose of 25mg/kg once daily for seventy days.

A veterinary professional will be able to recommend the correct dosage and duration of administration for your dog.

Research on Ideal Dosage of Tylosin

Biomedical Center institute performed research to determine whether the administration of 25mg/kg dose of Tylosin once daily for seven days proved effective in controlling canine Tylosin-responsive diarrhea. The research aimed to compare the result of a 5mg/kg and 15mg/kg Tylosin dosage to the regular 25mg/kg dosage daily. Fifteen dogs that have already been treated with 25mg/kg once daily were administered for the research.

The fifteen dogs were divided into two groups (eight and five). The first was given 5mg/kg while the other was given 15mg/kg. The first group of eight dogs responded to the 5mg/kg dose and for the remaining group, six of the seven dogs responded to the 15mg/kg dose.

After the entire research, it was revealed that dogs could be administered a suitable dosage of 15mg/kg or as low to 5mg/kg of Tylosin for treating diarrhea relapse.

How to Administer Tylosin

  1. Orally, it can be administered to dogs in powder via capsule formulations. Veterinary compounding pharmacies can add flavorings to these to disguise the substance’s strong taste and make it more palatable for dogs. It can also be administered through liquid via teaspoonful.
  2. Via injection.

Where Can I Buy Tylosin?

Tylosin can be purchased at the here on this website.

Top Tylosin Products for Dogs

They are various Tylosin product in the market, some of the top and best recommended choices are:

1.     Tylan Soluble Powder

Tylan Soluble Powder
Tylosin Powder

Tylan Soluble Powder is an antibiotic food additive used in veterinary medicine to treat bacterial infections in a wide range of species, including farm animals. In chickens, it is as an aid in the treatment of (CRD) chronic respiratory disease, in turkeys it helps to reduce the severity of effects of infectious sinusitis, in swine in help to treat and control dysentery, and in honey bees, it can help control American Foulbrood. It may also be recommended for off-label use in dogs and cats.   

2.     Elanco Tylan 50

Tylan 50 Injection by Elanco is an antibiotic for use in cattle and swine only for the treatment of certain diseases. Each mL contains 50 mg of Tylosin activity in 50 percent propylene glycol with 4 percent benzyl alcohol and water for injection. Tylan 50 injection is administered intramuscularly.

3.     Tylosin 50 100g Soluble Powder

Tylan 50 Soluble Powder
Tylan 50 Powder

Tylosin 50 100g Soluble Powder is an antibacterial powder which is white to light yellow in color with a specific smell. It is composed of Tylosin tartrate 500 mg and is used on chicken and pigs. It is used for the prevention and treatment of enteritis in poultry, Glasser’s disease, vibriosis, spirochetosis, infectious sinusitis, synovitis, chronic respiratory diseases caused by pathogens sensitive to Tylosin.

While it is administered to pigs for the prevention of prevention and treatment of animals dysentery, necrotic enteritis, gastroenterocolitis, caused by pathogens sensitive to Tylosin.

4. Tylan 200

Tylan 200

This is an antibiotic medicine containing 200 mg Tylosin per ml. Tylan 200 is administered intramuscularly and is used in the treatment of diseases including bovine respiratory complex (shipping fever, pneumonia), foot rot, and diphtheria in beef cattle and non-lactating dairy cattle. It is used for the treatment of pneumonia and dysentery in swine weighing at least 25 lbs.

Tylosin vs Oxytetracycline

Tylosin is a macrolide antibiotic substance that is been used to treat bacterial or chronic infection in a farm animal, poultry animal and even pets such as dog and cats. The substance can be used to treat some chronic infections in dogs, such as chronic diarrhea, colitis, exocrine pancreatic insufficiency, inflammatory bowel diseases. Also, cosmetics issues in dogs such as tear staining can be treated with the use of Tylosin.

Differences in Use

Tylosin is of benefits to a farm animal and poultry animals it helps to boost their physical growth and prevents the spread of repository diseases among the animals. It is also administered differently in various countries which provides for the treatment of different diseases suffered by most animals. Some of its side effects include pain and local irritations at the injection site, diarrhea, anorexia, and an increase in blood levels etc.

Oxytetracycline is a tetracycline-type antibiotic which is primarily prescribed for the treatment of acne (spots) and rosacea. However, it can be used to certain bacterial infections such as bronchitis, pneumonia and mycoplasma infections. It ensures that the bacterial infection stops growing, multiplying and increasing in numbers.

This substance is different from Tylosin and it can be used to treat other rarer disease such as fever due to its composition. Also, unlike Tylosin, it can be used with other substance such as painkillers, contraception, anticoagulants, alcohol etc. Oxytetracycline is used in both dogs and cats to treat bacterial infections, including respiratory infections of the sinuses, wound infections, pneumonia, infections of the oral cavity and infections of the blood cells.

Oxytetracycline is a prescription drug and can only be obtained from a veterinarian or by prescription from a veterinarian and it must be taken on an empty stomach, maybe 2 hours before food intake or two hours after food intake because it comes as 250mg tablets. Some of its common side effects include diarrhea, stomachache, the feeling of being sick, loss of appetite etc.

Tylosin vs Metronidazole

Metronidazole is an antibiotic that is used to treat a wide variety of infections Giardia, Entamoeba, Trichomonas, and Balantidium. It also is used to treat anaerobic bacterial infections. It works by stopping the growth of certain bacteria and parasites. Metronidazole treats only certain bacterial and parasitic infections. It will not work for viral infections (such the as common cold and flu).

It can also be used with other medications to treat certain stomach/intestinal ulcers caused by a bacteria (H. pylori). Also, Metronidazole is a prescription antibiotic used in dogs and cats to treat various conditions such as inflammatory bowel disease, nonspecific diarrhea disorders, infections caused by Giardia, and periodontal disease. It treats a wide variety of disease and effectively stops inflammatory bowel disease.

Metronidazole is especially effective against anaerobic infections – bacteria that can live without oxygen. Possible side effects of metronidazole use in dogs and cats include Allergic reaction (labored breathing, hives, etc.), Drooling and gagging (the drug is very bitter), Vomiting, Loss of appetite, Diarrhea, Lethargy, Blood in the urine, or dark urine and Liver damage.

Frequently Asked Questions (FAQ) about Tylosin

1. Are Tylosin and Tylan the Same?

Tylosin, also prescribed under the names Tylan and Tylocine, is a macrolide antibiotic. Macrolide antibiotics are bacteriostatic medications, which means that they do not kill bacteria.

2. What is Tylosin Used for in Dogs?

Tylosin is an antibiotic typically used to treat bacterial infections in farm animals, but veterinarians often use it to treat certain types of chronic diarrhea in cats and dogs as well as Tear staining in Dogs. In some countries the powdered form is not approved for use in companion animals with bacterial infections, but it is common practice for veterinarians to prescribe this medication.

3. Is Tylosin Safe for Dogs?

Although Tylosin is yet to be approved by the FDA, veterinary professionals for the most part agree that the substance is safe and effective for treatments of Tear staining in dogs and other animals.

4. How do I Administer Tylosin to my Dog?

It is highly recommended that advice of a veterinary professional is sought before administering Tylosin. However, the administration can be done either orally or injected into the body.

5. What is Tylosin Responsive Diarrhea?

Tylosin Responsive Diarrhea (TRD) is the relapse of chronic diarrhea after administering Tylosin to a Canine. A major feature of this is that diarrhea usually stops within a few days after use, however after administration ceases diarrhea often reappears within a few days. Tylosin-responsive diarrhea (TRD) is most typically seen in middle-aged, large-breed dogs.

6. What are other common names for Tylosin?

Tylosin can also be prescribed under the names Tylan and Tylocine. They are the same substance, which is a macrolide antibiotic.

7. Is Tylosin used for Domestic animals?

Tylosin was originally used to treat bacterial infections in farm animals, but it has gained favor with veterinarians in recent years. It is now used it to treat certain types of diseases and infections in dogs and cats. The FDA has only approved the use of Tylosin for farm animals, but professional veterinarians can legally prescribe Tylosin as medication.

8. What if my dog doesn’t respond to treatment with Tylosin?

Your dog not responding to treatment using Tylosin is a possibility to be considered, because as a macrolide substance, Tylosin does not actually kill bacteria in the body. In this case, alternative treatment should be sought, as long-term use of Tylosin is discouraged.

9. Can Dogs be on Tylosin for Life?

Even though long term use of Tylosin is discouraged because of the potential for the development of bacterial resistance, there isn’t a limit on the length of time Tylosin can be used for Tear Stain removal.

10. How Quickly Does Tylosin Work?

Depends on what your are using it for. For Tear Stain removal you may notice results in as short as a week. For diarrhea, it can work in as shot as 24 hours and may take up to three days.

Usage, Dosage, Safety and Administration

Tylosin is an antibiotic substance, most often used in treatment of gastrointestinal disorders in dogs. It has proved to be effective in relieving symptoms of discomfort in dogs suffering from bowel disorders. However, research on Tylosin to this day remains limited. This is primarily because it is only in recent years that it has made a transition from being used on commercial livestock to companion animals. Even though its use is becoming more mainstream in veterinary medicine, it has yet to be approved by the FDA for domestic pets, like cats and dogs.

It can be administered to a dog legally, if it is prescribed by a veterinarian. There are variety of ways in which Tylosin can be administered. These include oral or through an injection, which is often considered preferable due to the drug’s bitter taste. Additionally, there is no standard dosage and the dog’s specific circumstances must be considered by a vet in order to recommend the ideal dose. Age, weight, and general health all make a difference, as do any other medications a dog is already on. These include heart medications and other antibiotics that can mitigate Tylosin’s effectiveness and increase levels of toxicity to dangerous levels.

As with every drug, it is highly recommended that dogs are monitored when taking this medication. While there are no major side-effects associated with the use of Tylosin, dogs may present some gastrointestinal problems after first taking it. However, if a dog’s behavior changes after taking Tylosin for the first time, it is important to mention that to the veterinarian in order to assess whether to discontinue the medication. Allergies are also not uncommon.

Cautious use of Tylosin under a veterinary professional’s guidance can provide significant health benefits to dogs.


Buy Tylosin for your dog here.

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